What are cultured cells?
- Cells isolated purely from organism tissues, which can be cultured and proliferated in vitro for research purposes while maintaining their intrinsic characteristics
- Cultured cells refer to human or animal cell lines or organoids that can be used in distribution for cell biology, oncology, virology, neurobiology, and related research.
Applications
Research for developing therapeutics such as anticancer drugs
Basic biomedical research including cell culture and characterization
Biomedical research for advancing healthcare services
Organoid development research for regenerative and precision medicine
Why is the development of cultured cell resources and industry important?
- Allows reproducibility, genetic manipulation, and anticancer drug testing using identical cells; serves as an alternative to animal models in drug development and cancer research
- With global advances in 3D cultured cell techniques like organoids, domestic development and acquisition are needed to establish a distribution system for diverse cell lines and organoids.
- Development can take up to one (1) year, with ongoing management and maintenance costs, making cultured cell development and acquisition challenging.
Operates domestic support institutions and infrastructure that promote research and industrial development in cell culture through activities such as securing new cultured cells, improving quality, and mass cultivation
Key institutions and research cases on cultured cell resources
Cultured cell cluster and central bank “Korean Cell Line Bank”
- Cultured cell cluster : An institution that supports the expansion of high-quality cultured cell distribution and the promotion of research using these resources
- Korean Cell Line Bank : Performs customized cultured cell development, characterization and resource preparation, acquisition of cultured cell resources, contract research services, quality enhancement of cell resources and related information, and secured cultured cell resources for disaster response
Research case: “Prediction of Molecular Heterogeneity and Anticancer Drug Response from Single-tumor-derived Colorectal Cancer Organoids (2022)”
- Research conducted by Professors Koo Ja-rok and Chung Seung-yong at Seoul National University College of Medicine focused on intratumoral heterogeneity, which affects drug resistance and recurrence, using colorectal cancer organoids
- The study revealed that colorectal cancer is highly heterogeneous at genomic and transcriptomic levels within a single tumor, confirming the potential for more accurate prediction of drug responses, which will be used in future research to overcome anticancer drug resistance caused by intratumoral heterogeneity.
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